(1) 药物分析
(2) 中药药效物质基础
(3) 中医方剂

1、科研项目
（1）江苏省药品监督管理局，药品监管科学科研计划课题，202016，围绕“类结构表征”构建基于集成色谱技术的中药挥发油质量评价方法，2021-01 至 2023-12，10万元，在研，主持
（2）江苏省科技厅，江苏省自然科学基金面上项目，BK20161456，基于组合代谢特质的柴胡皂苷源性成分体内分析技术的构建及其应用，2016-07-01 至 2019-06-30，10万元，结题，主持
（3）国家自然科学基金委员会，青年项目，81403314，基于肠肝循环关键代谢酶和转运体介导的药物相互作用研究大黄-黄芩药对配伍机制，2015-01-01 至 2017-12-31，23万元，结题，主持
（5）江苏省科技厅，江苏省自然科学基金青年基金项目，BK2012349，大黄生熟异治作用的物质基础及炮制机理研究， 2012-07 至 2015-06，20万元，结题，主持
2、学术获奖
2018，江苏省教育厅，江苏省教育教学与研究成果奖三等奖：代谢组学分析关键技术创新及其在药物毒性个体化评价与预测中的应用，排名第五。

1.Qiwei Liu, Yunwen Xue, Jingjing Liu, Siqi Ren, Jie Xu, Jinni Yang, Yuanyue Xing, Zunjian Zhang, Rui Song*. Saikosaponins and the deglycosylated metabolites exert liver meridian guiding effect through PXR/CYP3A4 inhibition. J Ethnopharmacol. 2021, 279:114344. (IF: 5.195)
2.Min Wang, Jie Xu, Yuxin Zhang, NaYang, Weihong Ge*, Rui Song*. Integrated multiplatform-based metabonomics and network analysis to explore the mechanism of Polygonum cuspidatum on hyperlipidemia. J Chromatogr B Analyt Technol Biomed Life Sci. 2021, 1176:122769. (IF: 3.318)
3.Siqi Ren, Jingjing Liu, Yunwen Xue, Mei Zhang, Qiwei Liu, Jie Xu, Zunjian Zhang, Rui Song *. Comparative permeability of three saikosaponins and corresponding saikogenins in Caco-2 model by a validated UHPLC-MS/MS method. J Pharm Anal. 2021, 11(4):435-443. (IF: 14.206)
4.Zhang Yaqing, Zhang Mei, Hu Guangnan, Zhang Zunjian, Song Rui*. Elevated system exposures of baicalin after combinatory oral administration of rhein and baicalin: Mainly related to breast cancer resistance protein (ABCG2), not UDP-glucuronosyltransferases. J Ethnopharmacol. 2020, 250:112528.( IF:4.360)
5.Fu Ruijia, Liu Jingjing, Xue Yunwen, Zhang Zunjian, Song Rui*. Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b2 on the Pharmacokinetics of Saikosaponin a in Rats. Eur J Drug Metab Pharmacokinet, 2019, 44(6):827-836. (IF: 1.913)
6.Liu Jingjing, Xue Yunwen, Sun Jianbo, Fu Ruijia, Ren Siqi, Zhang Zunjian, Song Rui*. Pharmacokinetics and oral bioavailability studies of three saikogenins in rats using a validated UFLC-MS/MS method. Journal of Chromatography B, 2019, 1124:265-272. (IF: 3.004)
7.Xue Yunwen, Liu Jingjing, Fu Ruijia, Gao Lei, Yang Xuping, Zhang Zunjian*, Song Rui*. In vitro studies on the metabolism of saikogenins and the detection of their metabolites in authentic biosamples. J. Pharm. Biomed. Anal.2019, 172:295-301.( IF:3.209)
8.Yaqing Zhang, Zunjian Zhang, Rui Song *. The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma. Eur J Drug Metab Pharmacokinet, 2018, 43(3), 291-300. (IF: 1.497)
9.Mei Zhang, Yong Zhang, Siqi Ren, Zunjian Zhang, Yongren Wang*, Rui Song *. Optimization of a pre-column OPA derivatization HPLC assay for monitoring of L-asparagine depletion in serum during L-asparaginase therapy. J Chromatogr Sci. 2018, 56(9):794-801. (IF: 1.216)
10.Fu jinfeng, Songyan Wu, Yuan Tian, Zunjian Zhang*, Rui Song*. Intestinal metabolism of Polygonum cuspidatum in vitro and in vivo. Biomed. Chromatogr.,2018; 32 (6):e4190.( IF:1.748)
11.Pei Yu, Hongcong Qiu, Min Wang, Yuan Tian, Zunjian Zhang*, Rui Song*. In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes, Xenobiotica, 2017 47(1):11-19. (IF: 1.723)