(1) 药物经皮递送及化妆品
(2) 伤口愈合相关医疗器械与人造皮肤
(3) 纳米制剂基本性质对其体内命运的影响

1、代表性科研成果
(1) 采用小球藻治疗糖尿病溃疡。证明了小球藻可以同时改善多重溃疡组织微环境，包括：逆转缺氧、清除ROS、代谢葡萄糖、提供营养、抗炎等。其治疗效果显著，伤口愈合效率与急性伤口无显著差异。该研究成果发表在Acta Pharm Sin B, 2022。
(2) 探究了胆固醇调节的脂质体膜刚柔性对肿瘤渗透和抗肿瘤作用的影响。证明了脂质体膜的刚性随着胆固醇的添加而降低，而中等刚性的脂质体具有优异的肿瘤渗透性和抗肿瘤作用。该研究成果发表在Acta Pharm Sin B, 2019。

1.Wu, H.Y.; Yang, P.; Li, A.Q.; Jin, X.; Zhang, Z.H.*; Lv, H.X.* Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing, Acta Pharm Sin B. 2022 online. (IF: 14.9)
2.Lu, X.Y.; Wu, H.Y.; Liang, Y.P.; Zhang, Z.H.*; Lv, H.X.* Redox-responsive prodrug for improving oral bioavailability of paclitaxel through bile acid transporter-mediated pathway. Int J Pharm. 2021;600;120496. (IF: 6.5)
3.Zhang, S.#; Song, W.T.#; Wu, H.Y.; Wang, J.; Wang, Y.L.; Zhang, Z.H.*; Lv, H.X.*. Lecithins-Zein nanoparticles for antifungal treatment: Enhancement and prolongation of drug retention in skin with reduced toxicity. Int J Pharm. 2020;590;119894. (IF: 5.9)
4.Liang, P.; Wu, H.Y.; Zhang, Z.H.; Jiang, S.L.*, Lv, H.X.*. Preparation and characterization of parthenolide nanocrystals for enhancing therapeutic effects of sorafenib against advanced hepatocellular carcinoma. Int J Pharm. 2020;583;119375. (IF: 5.9)
5.Wu, H.Y.; Yu, M.R.; Miao, Y.Q.; He, S.F.; Dai, Z.; Song, W.Y.; Liu, Y.; Song, S.; Ahmad, E.; Wang, D.K.*; Gan, Y.* Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect. Acta Pharm Sin B. 2019;9;858-870. (IF: 6.0)

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