(1) 基于炎症和抗肿瘤药物的设计与评价研究
(2) 活性天然产物的结构改造和成药性优化研究
(3) 金属催化的小分子药物的合成方法学研究

1、科研项目
（1）江苏省科技厅，江苏省自然科学基金，BK20181333，江苏省自然科学基金，新型FGFR4特异性共价抑制剂的设计、合成及抗肝癌活性研究，2018-7 至 2021-06，10万元，已结题，主持
（2）国家自然科学基金面上项目，214722437，，新型基于吡咯[4,3,2-de]喹啉类STAT3抑制剂的设计、合成与抗肿瘤活性研究，2015-01-01 至 2015-12-31，40万元，已结题，主持
（3）国家自然科学基金面上项目，21172265，基于DFG-out型VEGFR/FGFR双重抑制剂的设计、合成及血管生成抑制活性的研究，2012-01至2015-12，60万元，已结题，主持
（4）2010年江苏省高校”青蓝工程“中青年学术带头人
2、学术获奖
（1）2018年，江苏省教育教学与研究成果奖，排名第三

1.Li W, Zhang C, Zhang H-e, Dong R, Liu J-y, Wang C-m, Wang M, Wang Y-w, Wang C, Zhang Y, Shi L, Xu Y, Sun L-P， Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors[J]. Bioorganic Chemistry, 2022, 127: 105917. (IF:5.307)
2.Li W, Zhang J-y, Wang M, Dong R, Zhou X, Zheng X, Sun L-P. Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery[J]. Current Topics in Medicinal Chemistry, 2022, 22(4): 284-304. (IF:3.57)
3.Dong R, Zhang C, Wang C, Zhou X, Li W, Zhang J-Y, Wang M, Xu Y, Sun L-P. Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2022, 55: 116592. (IF：3.461)
4.Dong R, Zhou X, Wang M, Li W, Zhang J-Y, Zheng X, Tang K- x, Sun L-P. Discovery of 4-amino-1H-pyrazolo [3, 4-d] pyrimidin derivatives as novel discoidin domain receptor 1 (DDR1) inhibitors[J]. Bioorganic & Medicinal Chemistry, 2021, 29: 115876. (IF:3.461)
5.Tang K- x, Wang C-M, Gao T-H, Chen L, Fan L, Sun L-P. Transition Metal‐Catalyzed C− H Bond Functionalizations by Use of Sulfur‐Containing Directing Groups[J]. Advanced Synthesis & Catalysis, 2019, 361(1): 26-38. (IF： 5.451)
6.Wang C-M, Tang K- X, Gao T-H, Chen L, Sun L-P. Cu (II)-Catalyzed Ortho-C–H Nitration of Aryl Ureas By C–H Functionalization[J]. The Journal of Organic Chemistry, 2018, 83(15): 8315-8321. (IF: 4.748)
7. Xue Y, Song P-R, Song Z-L, Wang A-L, Tong L-J, Geng M-Y, Ding J, Liu Q-S, Sun L-P, Xie H, Zhang A. Discovery of 4, 7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido [5, 4-b] pyrrolizines as Novel Bruton’s Tyrosine Kinase Inhibitors[J]. Journal of Medicinal Chemistry, 2018, 61(10): 4608-4627. (IF: 6.054)
8.Tang K., Chun-Meng Wang, Tian-Hong Gao, Cong Pan and Sun L-P,, Pd-catalyzed C–H arylation of benzothioamides with boronic acids using thioamides as directing groups, Org. Chem. Front., 2017, 4(11), 2167-2169.(IF： 5.455)
9.Zhang H.，F. Gong，J.g Ye，C. Zhang，X. Yue, C. Li，Yun-.n Xu, Sun L-P,, Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2., Eur. J. Med. Chem.,2017,125,245-254. (IF:4.816)
Zhang H., F. Gong, C. Li, C. Zhang, Y. Wang, Y. Xu, Sun L-P, Design and discovery of 4-anilinoquinazoline-acylamino derivatives as EGFR and VEGFR-2 dual TK inhibitors,Eur. J. Med. Chem., 2016, 109,371-379.(IF: 4.519)