1. 手性药物分子及先导化合物设计合成
2. 目标导向功能性杂环化合物设计合成
3. 活性天然产物全合成及结构修饰

1.Qiuyu LiФ, Xinxin FangФ, Rui Pan, Hequan Yao*, Aijun Lin*, Palladium-catalyzed asymmetric sequential hydroamination of 1,3-enynes: enantioselective syntheses of chiral imidazolidinones. J. Am. Chem. Soc. 2022, 144, 11364-11376. (Фequal contribution, IF = 16.38)
2.Chunhua Han, Libo Cai, Dongquan Zhang, Rui Pan, Qiuyu Li, Aijun Lin*, Hequan Yao*. Site-selective palladium-catalyzed 1,1-arylamination of terminal alkenes. CCS Chem. 2022, 4, 616-624.
3.Dongquan Zhang, Miaomiao Li, Jiajia Li, Aijun Lin*, Hequan Yao*. Rhodium-catalyzed intermolecular enantioselective Alder–ene type reaction of cyclopentenes with silylacetylenes. Nat. Commun. 2021, 12, 6627. (IF = 17.69)
4.Ziwen FengФ, Qiuyu LiФ, Long Chen, Hequan Yao*, Aijun Lin*. Palladium-catalyzed asymmetric carbamoyl-carbonylation of alkenes. Sci. China Chem. 2021, 64, 1367-1371. (IF = 10.14)
5.Zhenbo Yuan, Yuye Zeng, Ziwen Feng, Zhe Guan, Aijun Lin*, Hequan Yao*. Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes. Nat. Commun. 2020, 11, 2544. (IF = 14.92)
6.Zhenbo Yuan, Ziwen Feng, Yuye Zeng, Xiaobin Zhao, Aijun Lin*, Hequan Yao*. Palladium‐catalyzed asymmetric intramolecular reductive Heck desymmetrization of cyclopentenes: access to chiral bicyclo[3.2.1]octanes. Angew. Chem. Int. Ed. 2019, 58, 2884-2888. (IF = 12.96)
7.Chunhua Han, Zhiyuan Fu, Songjin Guo, Xinxin Fang, Aijun Lin*, Hequan Yao*. Palladium-catalyzed remote 1,n‑arylamination of unactivated terminal alkenes. ACS Catal. 2019, 9, 4196-4202. (IF = 12.35)
8.Shang Gao, Hao Liu, Zijun Wu, Hequan Yao*, Aijun Lin*. Palladium-Catalyzed Allylic Alkylation with Internal Alkynes to Construct C-C and C-N Bonds in Water. Green Chem. 2017, 19, 1861-1865. (IF = 8.57)