1、教育经历
(1) 1987/08-1991/05， The Ohio State University，生物化学，博士
(2) 1982/02-1984/12， 北京农业大学，生物化学，硕士
(3) 1978/02-1982/02， 浙江农业大学，兽医学，学士
2、工作经历
1991-1993 Human Frontier Science Program Fellow, Department of Biochemistry, University of Wisconsin-Madison and National Magnetic Resonance Facility at Madison, USA
1993-1999 Assistant Professor, Department of Biochemistry, Michigan State University, East Lansing, Michigan, USA
1999-2004 Associate Professor, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, USA
2004-2020 Professor, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA
2001-至今 教授，中国药科大学
3、学术荣誉
1990-1991 Proctor & Gamble Fellowship
1991-1993 Human Frontier Science Program Fellowship
2004 Guest Professor, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
2006 Guest Professor, Peking University, China
2010 Oversea eminent scholar and guest professor, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences
(1) 酶催化机制
(2) 基于靶点的药物研发
(3) 蛋白质相互作用
1.Achila, D., Liu, A., Banerjee, A., Li, Y., Martinez-Hackert, A., Zhang, J.-R., and Yan, H. (2015) Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae. Biochem. J. 465, 325-335.
2.Banerjee, R., Yan, H.*, and Cukier, R. I.* (2015) Conformational transition in signal transduction: metastable states and transition pathways in the activation of a signaling protein. J. Phys. Chem. B 119, 6591-6602.
3.Chen, B., Himes, P., Liu, Y., Zhang, Y., Lu, Z. W., Liu, A. Z., Yan, H.*, and Kroos, L.* (2014) Structure of bacterial transcription factor SpoIIId and evidence for a novel mode of DNA binding. J. Bacteriol. 196, 2131-2142.
4.Liu, A.*, Lu, Z., Wang, J., Yao, L., Li, Y., and Yan, H.* (2008) NMR detection of bifurcated hydrogen bonds in large proteins. J. Am. Chem. Soc. 130, 2428-2429.
5.Blaszczyk, J., Li, Y., Gan, J., Yan, H.*, and Ji, X.* (2007) Structural basis and catalytic mechanism for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase. J. Mol. Biol. 368, 161-169.
6.Yao, L., Yan, H.*, and Cukier, R. I.* (2007) A molecular dynamics study of the ligand release path in yeast cytosine deaminase. Biophys. J. 92, 2301-2310.
7.Wang, Y., Scherperel, G., Roberts, K. D., Jones, A. D., Reid, G. E.*, and Yan, H.* (2006) A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase. J. Am. Chem. Soc. 128, 13216-13223.
8.Sklenak, S., Yao, L., Cukier, R. I., and Yan, H. (2004) Catalytic mechanism of yeast cytosine deaminase. An ONIOM computational study. J. Am. Chem. Soc. 126, 14879-14889.
9.Shi, G., Blaszczyk, J., Ji, X.*, and Yan, H.* (2001) Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis, biochemical and X-crystallographic studies. J. Med. Chem. 44, 1364-1371.
10.Li, W. Scott, A. P., Siefkes, M. J., Yan, H., Liu, Q., Yun, S., and Gage, D. A. (2002) Bile acid secreted by male sea lamprey that acts as a sex pheromone. Science 296, 138-141.
