(1)药物经淋巴系统吸收、转运、代谢与递送
(2) 脂质制剂与脂-药衍生物

近年来在Journal of Controlled Release, Angewandte Chemie Int Ed等高质量专业期刊发表论文二十余篇，申请PCT专利十余项。2017年后与蒙纳士大学Chris Porter教授，Natalie Trevaskis副教授共同领导开创的淋巴系统导向脂质前体药物技术平台已授权勃林格殷格翰（里程碑合同额2.26亿美元），PureTech Health等知名企业合作开发。其中，别孕烯醇酮（Allopregnanolone）前体药物于2022年成功完成I期临床试验，是全球范围内淋巴导向创新药物里程碑式的突破。过往工作多次获美国药物科学家协会(AAPS)、国际控释学会(CRS)等全球性专业学术机构的年度最佳论文奖等奖项，受The Age等澳洲知名媒体广泛报道。

1.T Quach, L Hu, S Han*, SF Lim, D Senyschyn, P Yadav, NL Trevaskis, JS Simpson, CJH Porter*. Triglyceride-mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport. Front. Pharmacology, (2022) doi: 10.3389/fphar.2022.879660
2.Z Fu, S Li, S Han, C Shi, Y Zhang. Antibody drug conjugate: the ‘biological missile’ for targeted cancer therapy. Signal Transduction and Targeted Therapy, 7 (2022), 93
3.S Han*, L Mei, T Quach, CJH Porter, NT Trevaskis*. Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles. Pharm. Research, 38 (2021):1497-1518
4.R Kochappan, E Cao, S Han*, L Hu, T Quach, D Senyschyn, VI Ferreira, G Lee, S Lim, C Nowell, D Bonner, J Mintern, JS Simpson, NL Trevaskis*, CJH Porter*. Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice. J. Control. Release, 332 (2021), 636-651
5.G Lee, S Han, J Hong, ARJ Phillips, JA Windsor, CJH Porter, NL Trevaskis. Intestinal delivery in a long-chain fatty acid formulation enables lymphatic transport and systemic exposure of orlistat. Int. J. Pharmaceutics. 596 (2021), 120247
6.S Han, T Quach, L Hu, SF Lim, Gracia, NL Trevaskis, JS Simpson, CJH Porter. The impact of conjugation position and linker chemistry on the lymphatic transport of a series of glyceride and phospholipid mimetic prodrugs. J. Pharm. Sci. 110 (2021), 489-499
7.G Lee, S Han, I Inocencio, E Cao, J Hong, ARJ Phillips, JA Windsor, CJH Porter, NL Trevaskis. Lymphatic uptake of liposomes after intraperitoneal administration primarily occurs via the diaphragmatic lymphatics and is dependent on liposome surface properties. Mol. Pharmaceutics. 16 (2019), 4987-4999
8.S Han, L Hu, Gracia, T Quach, JS Simpson, GA Edwards, NL Trevaskis, CJH Porter. Lymphatic Transport of a Triglyceride Mimetic Prodrug in a Large Animal Model: Studies in Greyhound Dogs. Mol. Pharmaceutics. 13 (2016): 3351-3361 (Faculty 1000 recommended article)
9.L Hu#, T Quach# S Han#, SF Lim, NL Trevaskis, JS Simpson, CJH Porter. Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability. Angew Chem Int Ed Engl., 55 (2016), 13700-13705 (Frontispiece )
10.S Han, T Quach, L Hu, A Wahab, WN Charman, VJ Stella, NL Trevaskis, JS Simpson, CJH Porter. Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies. J. Control. Release, 177 (2014), 1-10 (Cover)

课题组正在组建中，欢迎对上述领域有兴趣的硕士、博士研究生与我沟通、报考；欢迎看好上述领域的博士后来访、详谈职业发展事宜。
在这小而精的课题组，每一位成员都会得到用心的指导，以及与世界一流科研单位/企业合作交流与合作研究的机会。
如果你平时常常享受深度学习与钻研问题时那种“心流”状态，可能你真的与科研有缘。希望我们共同开拓上述药物科学前沿领域的新疆界，开发可能写入未来教科书的新技术，助力涉及上亿患者临床需求的满足。