(1) 肝癌发病机制研究
(2) 非酒精性肝病发病机制研究
(3) 肝病关键分子靶向药物筛选

1、科研项目
（1）国家自然科学基金青年项目：TADA2B调控肝癌细胞p53蛋白功能的作用机制及其三维结构稳定性研究，2020/01-2022/12，21万
（2）江苏省双创博士项目：肝细胞癌发病机制研究，2019/01-2022/12， 15万
（3）南京市留学人员科技创新项目：肝癌中p53蛋白功能异常调控机制研究, 2020/01-2022/12，3万
2. 科研奖励
获欧洲肝病学会EASL青年科学家特别资助, EASL HCC SUMMIT , 2017

1.Wenhui Wang（王文辉）, Ron Simits, Haiping Hao, and Chaoyong He. Wnt/β-catenin signaling in liver cancers. Cancers 2019, 11(7):926. (IF: 6.575)
2.Wenhui Wang（王文辉）, Pengyu Liu, Marla Lavrijsen, Shan Li, Ruyi Zhang, Shanshan Li, Wesley S van de Geer, Harmen J G van de Werken, Maikel P. Peppelenbosch, and Ron Smits. Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Sci Rep 2021, 11(1):7470. (IF: 4.996)
3.Wenhui Wang（王文辉）, Pengyu Liu, Kostandinos Sideras, Harmen J G van de Werken, Marieke van der Heide, Wanlu Cao, Marla Lavrijsen, Maikel P Peppelenbosch, Marco Bruno, Qiuwei Pan, and Ron Smits. Oncogenic STRAP supports hepatocellular carcinoma growth by enhancing Wnt/β-catenin signaling. Mol Cancer Res 2019, 17(2):521-531. (IF: 6.333)
4.Wenhui Wang（王文辉）, Qiuwei Pan, Gwenny M. Fuhler, Ron Smits, and Maikel P. Peppelenbosch. Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma. J Gastroenterol 2017, 52(4):419-431. (IF: 6.772)
5.Wenhui Wang（王文辉）, Lei Xu#, Pengyu Liu#, Kiran Jairam, Yuebang Yin, Kan Chen, Dave Sprengers, Maikel P. Peppelenbosch, Qiuwei Pan, Ron Smits. Blocking Wnt secretion reduces growth of hepatocellular carcinoma cell lines mostly independent of β-catenin signaling. Neoplasia 2016, 18(12):711-723. (#, all these authors contribute to project equally) (IF: 6.218)
6.Xue-Fei Ma#, Ting-Ting Wang#, Wen-Hui Wang（王文辉）#, Li Guan, Chang-Run Guo, Xing-Hua Li, Yun-Tao Lei, Ying-Zhe Fan, Xiao-Na Yang, Motoyuki Hattori, Osamu Nureki, Michael X Zhu, Ye Yu, Yun Tian and Jin Wang. The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors. J Biol Chem 2022, Jun;298(6):102002. (#, all these authors contribute to project equally) (IF: 5.486)
7.Peng-Cheng Yu, Di Liu, Zeng-Xiang Han, Fang Liang, Cui-Yun Hao, Yun-Tao Lei, Chang-Run Guo, Wen-Hui Wang（王文辉）, Xing-Hua Li, Xiao-Na Yang, Chang-Zhu Li, Ye Yu and Ying-Zhe Fan. Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells. Front Pharmacol. 2022,15;13:779715. (IF: 5.988)
8.Pei-Lin Yang#, Xing-Hua Li#, Jin Wang#, Xue-Fei Ma, Bo-Ying Zhou, Yuan-Feng Jiao, Wen-Hui Wang （王文辉）, Peng Cao, Michael Xi Zhu, Pei-Wang Li, Zhi-Hong Xiao, Chang-Zhu Li, Chang-Run Guo, Yun-Tao Lei, and Ye Yu. GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6. J Biol Chem 2021, 297(4):101125. (#, all these authors contribute to project equally) (IF: 5.486)
9.Hendrikus J. Dubbink, Iris H.I.M. Hollink#, Carolina Avenca Valente#, Wenhui Wang#（王文辉）, Pengyu Liu, Michail Doukas, Max M. van Noesel, Winand N.M. Dinjens, Anja Wagner, and Ron Smits. A novel tissue-based β-catenin gene and immunohistochemical analysis to exclude Familial Adenomatous Polyposis among children with hepatoblastoma tumors. Pediatr Blood Cancer 2018, 65(6):e26991. (#, all these authors contribute to project equally) (IF: 3.838)
Wenshi Wang, Yuebang Yin, Lei Xu, Junhong Su, Fen Huang, Yijin Wang, Patrick P. C. Boor, Kan Chen, Wenhui Wang（王文辉）, Wanlu Cao, Xinying Zhou, Pengyu Liu, Luc J. W. van der Laan, Jaap Kwekkeboom, Maikel P. Peppelenbosch, and Qiuwei Pan. Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections. Sci Signal 2017, 10(476):eaah4248. (IF:9.517)

硕士研究生
居峰禹 （2022级）