(1) 情感障碍疾病的代谢调控靶标发现
(2) 基于“肠脑”信号传递的新药研发与临床前评价
(3) 中药体内过程与作用机理研究

1、科研项目
(1) 国家自然科学基金面上项目，82274009, 基于菌群代谢重塑与肠干细胞命运调控的利福昔明治疗 IBS-D机理研究，2023/01-2026/12， 52万元，在研，项目负责人
(2) 国家自然科学基金面上项目，81973556,“菌-肠-脑轴”犬尿氨酸代谢调控在人参皂苷抗抑郁中的作用及其PK-PD关联机制，2020/01-2023/12， 55万元，在研，项目负责人
(3) 国家自然科学基金青年项目，81503142，基于人参皂苷Rg1的肠道代谢处置和AhR/IL-22信号调控诠释其抗抑郁的药动-药效矛盾，2016/01-2018/12，18.4万元，已结题，项目负责人
(4) 江苏省自然科学基金青年项目，BK20141035, 基于脑肠轴犬尿氨酸代谢与功能调控的人参皂苷Rg1抗抑郁机制研究，2014/07-2017/07，20万元，已结题，项目负责人
2、学术获奖
2022, 江苏省科技奖一等奖，第5完成人

1.Zhou J, Fan Q, Cai X, Zhang Y, Hou Y, Cao S, Li Z, Feng M, Wang Q, Zhang J, Wang G, Zheng X*, Hao H*. Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism. Chin J Nat Med. 21(10):745-758 (2023). (IF:4.6)
2.Cheng L, Wu H, Chen Z, Hao H*, Zheng X*. Gut microbiome at the crossroad of genetic variants and behavior disorders. Gut Microbes. 15(1):2201156 (2023). (IF:9.434)
3. Zheng X#, Cai X#, Hao H*. Emerging targetome and signalome landscape of gut microbial metabolites. Cell Metabolism. 34(1):35-58 (2022). (IF:31.373)
4. Zhang Y#, Fan Q#, Hou Y#​, Zhang X, Yin Z, Cai X, Wei W, Wang J, He D, Wang G, Yuan Y*, Hao H*, Zheng X*. Bacteroides species differentially modulate depression-like behavior via gut-brain metabolic signaling. Brain Behavior Immunity102, 11-22 (2022). (IF:19.227)
5. Hou Y, Wei W, Guan X, Liu Y, Bian G, He D, Fan Q, Cai X, Zhang Y, Wang G, Zheng X*, Hao H*. A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut. Nature Communications 12, 271(2021). (IF:14.919)
6. Zhang X*, Cai X, Zheng X*. Gut microbiome-oriented therapy for metabolic diseases: challenges and opportunities towards clinical translation. Trends in Pharmacological Science. 42(12):984-987(2021). (IF:14.819)
7. Liu Y, Hou Y, Wang G, Zheng X*, Hao H*. Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host-Microbe Interplay. Trends in Endocrinology Metabolism 31, 818-834(2020). (IF:12.015)
8. Fan Q#, Guan X#, Hou Y, Liu Y, Wei W, Cai X, Zhang Y, Wang G*, Zheng X*, Hao H*. Paeoniflorin modulates gut microbial production of indole-3-lactate and epithelial autophagy to alleviate colitis in mice. Phytomedicine 79, 153345(2020). (IF:5.340)
9. Zheng X#, Hu M#, Zang X, Fan Q, Liu Y, Che Y, Guan X, Hou Y, Wang G*, Hao H*. Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress. Brain Behavior Immunity 79, 244-255 (2019). (IF:7.217)
10. Kang A, Xie T, Zhu D, Shan J, Di L*, Zheng X*. Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice. Journal of Agricultural and Food Chemistry 65, 6861-6869(2017). (IF:5.279)

郝海平教授
郑啸副教授
博士研究生
蔡晓莹（2022级）
尹佳婷（2023级）
硕士研究生
冯梦珍，李自光，曹书琪，张玄霜，司马静洁（2021级）
周俊池，陈卓，张洋帆，余思琦，潘雅蕊（2022级）
马庆云，王莹，汤任娇，陈紫昕，陈简（2023级）